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The central mission of the Penn TREC Survivor Center is to advance science on energetics and cancer survivorship, toward the goal of improving both the length and quality of cancer survivorship.

Project 2

Key Personnel
  • Kathryn H. Schmitz, PhD, MPH, FACSM
    Project Leader, Exercise Intervention Coordinator
  • David Sarwer, PhD
    Co-Investigator, Weight-Loss Intervention Coordinator
  • Angela DeMichele, MD, MSCE
    Co-investigator, Breast Oncologist
  • Carrie Stricker, PhD, RN
    Co-investigator, Lymphedema Rehabilitation Physician

Project 2: The Women in Steady Exercise Research (WISER) Survivor Trial

The goal of Project 2 is to assess the effects of exercise training and/or weight loss through caloric restriction on lymphedema, a common long term adverse effect of cancer treatment, biomarkers for recurrence and quality of life. This project will be a one year randomized controlled weight loss and exercise intervention trial in a multi-ethnic cohort of overweight and obese post-menopausal breast cancer survivors with lymphedema.

Specific Aims:

  1. Assess the effects of one year of exercise, weight loss or the combined intervention on clinical lymphedema outcomes including incident events requiring medical care for lymphedema, arm swelling in the affected limb and pain and lymphedema symptoms.
  2. Assess the effects of intervention on sex steroids, inflammatory markers, adipokines, oxidative stress, growth factors and pathogenic angiogenesis, a novel recurrence pathway.
  3. Assess the effects of intervention on quality of life outcomes including lymphedema quality of life and body image.